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Hormones can influence drug addiction a narrative review

10 Furthermore, modest reductions in weight (5 to 10%) can induce clinically significant improvements in these CVD risk factors, and the degree of benefit in terms of a reduction in CVD risk factors and clinical outcomes have been shown to increase with higher percentages of weight loss

McIntyre, C

The intervention lasted four weeks, followed by a two-week washout period, followed by four weeks in the other group