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As shown in Figure 7FG, BPC-157-induced tube formation was significantly inhibited by PD98059, but not by SP600125 and SB203580

and, deoxycorticosterone and THDOC ( Physiological Actions The physiologic effects of neurosteroids are mediated through direct interactions with neurotransmitter receptors and transporters, and indirectly via promotion of second-messenger signaling cascades ( The modulation of GABAergic neurotransmission by neurosteroids is mediated by interactions with allosteric sites on GABA A Rs ( A R subunits ( PregS is a relatively potent positive allosteric modulator of NMDAR-mediated synaptic transmission, while pregnanolone sulfate is a relatively potent negative allosteric modulator of NMDAR-mediated glutamatergic neurotransmission ( PregS is the most widely studied neurosteroid that potentiates NMDARs ( Xenopus oocytes have established that the effects of PregS are dependent on NMDAR subunit composition

(7) The effect was dose-dependent