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Description

Of note, increased CGRP content has been found in the airway submucosal glands of humans with CF, as well as in mice, ferrets, and pigs with CF [161]

It activates GHRH receptors in the pituitary, prompting increased release of growth hormone (GH) and downstream production of IGF-1, which contributes to lipolysis, metabolic improvements, and fat redistribution

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Because it targets specific inflammatory pathways rather than broadly suppressing immunity, the side effect profile appears minimal based on available research