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Studies of male pseudohermaphrodites with 5 -reductase-2 deficiency over the last 23 decades has highlighted the difference between testosterone and DHT in male sexual development, elucidated the significant roles of DHT in prostate physiology and pathophysiology, and led to the development of a specific 5 -reductase-2 inhibitor, finasteride, for the treatment of BPH and male pattern baldness

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