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This needs vasodilatation and permeability increase of the existent vessels and happens subsequently after hypoxia, in response to the production of chemokines and factors such as VEGF and ANG-2 by hypoxic cells (199)

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[PubMed: 16904799] (Evaluation of the safety of oral ALA in rats who exhibited no evidence of toxicity except at the highest doses tested [121 mg/kg], which was associated with minor ALT elevations in males and slight changes in liver histology including small droplet fat in periportal regions, but without frank hepatocyte necrosis or inflammation)