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What the science supports is a clear mechanism for supporting mitochondrial function and insulin sensitivity, which is why MOTS-c therapy is a thoughtful tool for patients whose weight loss resistance traces back to metabolic and mitochondrial dysfunction, without artificially suppressing appetite

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L-carnitine itself, as well as several of its metabolites, including GBB, crotonobetaine, and trimethylamine-n-oxide (TMAO), have been associated with cerebrovascular dysfunction and cardiovascular disease (Koeth et al., 2013, 2014, 2019

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