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As shown in Table 4 , miRNA levels change various intracellular pathways, and the most prominent implicated pathways are those of NF-B (192, 198, 207, 212, 213, 222, 229, 230, 238), PI3K/Akt (194, 199, 203, 236), JAK/STAT (218, 219), TLR (208, 220), -catenin (215, 217, 235), and Wnt (223, 235)

Histochemical and histological observations were performed as previously described (Reference Betancor, Sprague and Sayanova53,Reference Song, Gao and Hogstrand54)

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The more stress is placed on the liver, the faster this may lead to a dysfunctional liver and cause death