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This research demonstrates that GLP-1 safety extends beyond controlled clinical trials to everyday medical practice

The degree to which leptin and insulin stimulate overall GLP-1 secretion is still unclear, but GIP-mediated GLP-1 release has been shown to occur in rodents via acetylcholine release by the enteric nervous system

GLP-1 receptors are found in brain regions associated with reward and pleasure, so by modulating these pathways, semaglutide and tirzepatide may influence the rewarding aspects of food consumption