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MCAS is fundamentally a condition of inappropriate mast cell activation with little to no neoplastic proliferation, distinguished from mastocytosis

This may explain the hepatotoxic potential of this VPA metabolite and the development of liver failure in patients with a deficiency in the mitochondrial DNA replicase system, such as gamma polymerase [115]

Prior to initiating VYVANSE treatment, screen patients for risk factors for developing a manic episode (e.g., comorbid or history of depressive symptoms or a family history of suicide, bipolar disorder, and depression)

Structural and molecular basis for mitochondrial DNA replication and transcription in health and antiviral drug toxicity