[1] [2] Dietary modifications form the cornerstone of symptom management: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods that may exacerbate nausea Stay well-hydrated, particularly if experiencing diarrhoea Increase dietary fibre gradually if constipated, alongside adequate fluid intake Limit carbonated beverages and foods that cause bloating Eat slowly and chew food thoroughly to aid digestion For nausea management , patients often find relief by: Avoiding strong food odours during meal preparation Consuming bland, easily digestible foods such as toast, rice, or bananas Using ginger-based products (ginger tea or biscuits), which some patients find helpful Ensuring adequate rest and avoiding lying down immediately after eating Constipation can be addressed through: Increasing water intake to at least 68 glasses daily Regular physical activity, which stimulates bowel motility Gradually increasing dietary fibre from fruits, vegetables, and whole grains Considering over-the-counter laxatives after consulting your pharmacist or GP If side effects are severe or significantly impact quality of life, discuss with your prescriber whether dose adjustment or temporary treatment interruption might be appropriate
Persistent insomnia beyond 4-6 weeks despite implementing all strategies in this guide suggests either an unrelated sleep disorder or a contributing factor that has not been identified
Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF--induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells
Similarly, circulating ghrelin does not appear to modulate the behavioral responses of alcohol (70)
