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The guidance also says it does not intend to renew a funding mechanism for state health programs specific to Tennessees waiver called designated state investment programs or DSIP, approved by the Trump administration in 2021 and renegotiated by the Biden administration in 2023

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The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure