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Tirzepatide has a higher affinity with GLP-1R than GLP-1 does (pIC 50 : 8.90 vs 8.62), and its cAMP activation activity is significantly lower (12 decrease in pEC 50 )
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However, in murine models, exendin-4 demonstrates about 5,500-fold greater potency in improving glucose control, evidenced by the percentage fall in plasma glucose at 1 hour (87)
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This has led to speculation that GLP-2 may act indirectly on bone cells in humans, with the presence of GLP-2R on the parathyroid gland suggesting a potential link between GLP-2, PTH secretion, and bone turnover
![glp-1 degradation Drug Impurities & glp-1_analogs [TUSOM | Pharmwiki]](https://www.mdpi.com/ijms/ijms-21-08404/article_deploy/html/images/ijms-21-08404-g006-550.jpg)
Diabetologia 47 , 806815 (2004)
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