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The indication for prophylactic pharmacotherapy depends on attack intensity (more than every 12 months) and severity (exceeding 2 days or requiring hospitalization), the impairment of the QoL (e.g., frequent school absences) and if attack treatments are ineffective or cause side effects
"Dietary Bacillus subtilis supplementation alleviates alcohol-induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice." Experimental and Therapeutic Medicine 22.5 (2021)
Wipe the rubber stoppers of both vials with alcohol pads and allow them to air dry for at least 30 seconds
doi: 10.3389/fnut.2021.780205
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