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Call your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools increased risk of low blood sugar (hypoglycemia), especially those who also take medicines for diabetes such as insulin or sulfonylureas

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This process involves the nuclear localization signal, allowing NRF2 to traverse the nuclear pore and enter the cell nucleus

This is thanks to several molecular modifications that enhance semaglutides ability to bind to plasma proteins, while making it more resistant to degradation by enzymes such as DPP-4 [3]