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At the drug-class level, ALT decreased in NAFLD, NAFLD or NASH, and T2DM with NAFLD (all Class IV

DOI: 10.1039/9781839165894-00001

According to the UK SmPC, the most frequently reported adverse effects include nausea (occurring in approximately 44% of patients), diarrhoea (30%), vomiting (24%), constipation (24%), and abdominal pain (20%)

The anti-inflammatory effects of n-3 PUFA are based on their ability to decrease endogenous concentrations of ROS and expression of NF-kB and promote activation of genes involved in antioxidant protection