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When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991
Limiti dei dati di sicurezza: La principale limitazione riguarda la mancanza di dati di sicurezza a lungo termine nell'uomo
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E, American association of clinical endocrinologists, american college of endocrinology, and androgen excess and pcos society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome
Even with prolonged fasting, the drug slows the natural contraction of the stomach, leaving undigested food and gastric secretions in the digestive tract
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