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Accordingly, provided herein are methods for sterilization of auris formulations that prevent degradation of polymeric components (e.g., thermosetting and/or gelling and/or mucoadhesive polymer components) and/or the therapeutic agent during the process of sterilization

In the presence of redox-active metals, particularly copper, GSH serves as a physiological reducing equivalent donor within these coupled reactions, contributing to the generation of Cu + from Cu 2+ under defined chemical or catalytic conditions

PMID 31172600

GPX4 inhibition enhances glioma radiosensitivity by inducing oxidative stress-dependent SSG and degradation of transglutaminase 2 (TGM2), impairing DNA repair 126