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Primary Results of ROSE/TRIO-12, a Randomized Placebo-Controlled Phase III Trial Evaluating the Addition of Ramucirumab to First-Line Docetaxel Chemotherapy in Metastatic Breast Cancer

However, under conditions of oxidative stress, superoxide radicals (O2) react with NO to form ONOO , reducing the bioavailability of NO and leading to endothelial dysfunction [67]

This strategy has been applied in clinical trials for oncology and hematopoietic stem cell transplant (16, 17)

Almost 90% of cellular GSH resides in the cytosol, with roughly 10% found in the mitochondria and a small fraction in the endoplasmic reticulum