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APOM, by binding sphingosine-1-phosphate (S1P), not only triggers anti-inflammatory signaling via S1P receptors but also suppresses inflammation by inhibiting NF-B nuclear translocation through the PI3K/AKT pathway [55, 56]

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If you are experiencing inflammatory spine symptoms, your care provider can order blood tests looking for any anemia, inflammation tests such as a CRP or ESR looking for inflammation, and x-rays of the sacroiliac joints which is generally where the disease begins