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Kumar et al 89 reported 1 in 753 and Mangwana and Bedi90 as 1 in 974

However, market share consolidation from 94.3% in 2025 to an estimated 62.1% by 2034 is projected as tirzepatide, MariTide, and emerging alternatives capture increasing proportions of diabetes and obesity treatment markets

Kidney and liver function, body weight, age, and concurrent medications all modulate clearance rates

These issues reflect Cochrane Librarys recommendation for need for independent evidence, both for the short-term and long-term use of GLP-1s