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Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)

369 Recent studies have demonstrated that neutrophil death in SLE involves ferroptosis, which is characterized by morphological changes such as vacuole formation, disappearance of mitochondrial cristae, and increased membrane density in mitochondria

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