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Some studies have reported that depression caused by chronic stress disrupts the BDNFtropomyosin related kinase B (TrkB) receptor signaling pathway in the PFC and hippocampus, and ultimately contributes to impaired synaptic maturation, synaptic protein synthesis, and glutamate receptor cycling (Collingridge et al., 2010

They are easier to stop than injections if side effects are bad

Blood glucose control may begin to deteriorate within one to two weeks after the final injection, though some glucose-lowering effect may persist for up to four weeks due to residual drug levels

207,208 Several plant-derived bioactive compounds upregulate SIRT1 expression or enzymatic activity via diverse mechanisms, showing positive effects in MASLD-related studies