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Quality of evidence: I-A, Strength of recommendation: 1 Panel level of agreement: In total agreement 96%, in partial agreement 4% Lactulose is the most widely used nonabsorbable disaccharide for the treatment of HE

Current ROS-targeted interventions include antioxidant therapies, conventional pro-oxidant therapies, and other emerging novel approaches modulating ROS homeostasis

Asia-Pacific is expected to be the fastest-growing region at a CAGR of 9.4% from 2026 to 2033, fueled by the rapidly increasing diabetic population, expanding healthcare infrastructure, rising healthcare expenditure, and improving access to advanced biologic therapies across China, India, Japan, and South Korea

Nox4-deficient HSCs exhibit impaired activation and collagen I synthesis