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These structural features explain the promiscuity of Cg DHDPR in regard to cofactor preference between NADH and NADPH

This result was confirmed statistically using a non-parametric analysis of variance (KruskallWallis test), followed by post-hoc analysis (Wilcoxon method) that showed the procedural blank froze at a significantly different temperature than all of the compounds (Supplementary Table 2)