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For example, a 2010 study demonstrated that central administration of pan-melanocortin agonist MT-II decreased food intake in WT, Mc3r KO, and Mc4r KO mice ( Previous melanocortin agonist clinical candidates (20042022) In the early 2000s, several MC agonists were developed and trialed as weight management therapies

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Toxin and drug exposure Some also hypothesise that toxin exposure could trigger ME/CFS (61), such as organophosphate compounds (152, 153) and heavy metals (154)