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Unlike conventional toxicity, further exposure of a sensitized animal (or man) will elicit a harmful allergic reaction after a much smaller dose than that required for sensitization, although there will still be a graduation of the severity and nature of the hypersensitivity reaction, for example ranging from slight bronchoconstriction to fatal bronchospasm or anaphylaxis after respiratory challenge

However, when combined with insulin or sulfonylureas, hypoglycaemia risk increases, and dose adjustments of these concomitant medications may be required

Neuropharmacology 110, 396406

The guidance above is based on clinical principles only