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Existen dos formas activas principales: GLP-1(7-36) amida con 30 aminocidos (la forma predominante en circulacin) y GLP-1(7-37) con 31 aminocidos
Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]
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