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Wang C, Li X, Wang H, Xie Q, Xu Y (2014) Notch1-nuclear factor B involves in oxidative stress-induced alcoholic steatohepatitis

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By selectively activating melanocortin receptors, Melanotan 2 influences melanin production, UV response, and other pigmentation-related cellular processes

For the purpose of the trial, obesity in East Asians was defined as having 'a BMI of 35kg/m 2 or higher with at least one obesity-related comorbidity such as hypertension, hypercholesterolemia, or type 2 diabetes,' or 'a BMI of 28kg/m 2 or higher with at least two obesity-related comorbidities.' The participants were divided into three groups and were respectively administered a weekly dose of 2.4mg, a weekly dose of 1.7mg, or a placebo, with the results compared and analyzed after 68 weeks