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This broad receptor engagement profile means that Melanotan II simultaneously activates melanogenic pathways (MC1R on melanocytes), appetite and energy homeostasis circuits (MC3R/MC4R in hypothalamus), and exocrine gland function pathways (MC5R), making it essential for researchers to design appropriate controls and selective antagonists into experimental protocols to attribute observed effects to specific receptor subtypes

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Next, we demonstrated ferroptosis-induced accumulation of cellular lipid hydroperoxides following RSL3 treatment