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Ferroptosis, a distinct form of cell death driven by iron-dependent lipid peroxidation, serves a key role in several biological processes, including development, aging, immune regulation and cancer (1416)

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Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models