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Higher doses (12.515 mg/week) may be used in subsequent phases if tolerated and clinically indicated

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Therefore, oxidative stress is the suggested mechanism of T-2 toxicity as LC 50 of 10 ng/mL induces apoptosis in HeLa cells through caspases dependent and independent pathways ( c , apoptosis-inducing factor (AIF), and caspases 9, 3, and 7 (Table 2) (110)

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