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The present review aims to elucidate the mechanisms by which copper ions are involved in cardiovascular diseases, summarize the impact of copper ion abnormalities on cardiovascular diseases and potential therapeutic approaches, and investigate whether modulating copper ion levels can ameliorate cardiovascular diseases

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(8) Research has documented that IGF-1 signaling plays important roles in insulin sensitivity and substrate metabolism, and IGF-DES provides a tool for studying these effects independent of IGFBP modulation