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have recently demonstrated a better modulatory effect on granulation tissue in excisional wounds in genetically modified diabetic mice db/db in comparison to PDGF-BB (which is the only approved medication for diabetic ulcers treatment) (17)
Interspecies scaling (for example, body-surface-area conversion) typically reduces a rodent mg/kg figure severalfold, and even a properly scaled number would still be a hypothetical exposure , not a validated dose
For this reason, dermatology is becoming an important part of the GLP-1 conversation
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