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Berberine can also help your body respond to insulin better, but not likely as well as metformin

257 , E175E179 (1989)

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Yet another aspect of the invention is to provide a method for treating patients not responsive to a PDE-5 inhibitor alone, the method including administering both PT-141 and a PDE-5 inhibitor, wherein the PDE-5 inhibitor is administered subsequent to administration of PT-141