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117 Interestingly, glucagon also exerts insulinotropic effects on islet beta-cells, and this is likely to allow for tissues to uptake glucose and fat once glucagon has induced their catabolism from nutrient storage (as tissues such as skeletal muscle rely on insulin for nutrient uptake from circulation), or the insulinotropic effects of glucagon could simply serve as a feedback inhibition mechanism
Because digoxin toxicity can present as nausea and vomiting, symptoms that overlap with GLP-1 RA side effects, maintain a low threshold for checking levels in any patient reporting new or worsening GI symptoms after a GLP-1 RA dose increase
I frequently remind patients that fatigue, headaches, or constipation on GLP-1s arent always side effects of the medication itselftheyre often signs of dehydration
GSH depletion has been identified as an early-stage event in the pathogenesis of Parkinson's disease, occurring before the loss of dopaminergic neurons becomes clinically apparent
