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This bifurcation Akt/mTORC1 for protein synthesis, ERK1/2 for proliferation represents the canonical dual anabolic output of IGF-1R activation, and both arms are relevant to skeletal muscle research depending on the biological question (hypertrophy vs regeneration)
doi: 10.1038/mp.2015.29 229 BroderickGFuiteJKreitzAVernonSDKlimasNFletcherMA
El estudio identifica este mecanismo pro-angiognico como clave en sus efectos reparadores)pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov
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