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Plasma non-esterified fatty acid (NEFA) levels were measured using Lab Assay NEFA (FUJIFILM Wako Laboratory Chemicals)
However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease
A meta-analysis found that people taking GLP-1 RAs (including semaglutide) lose an average of 11% of their starting weight
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