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A 2024 assessment of registered clinical trials on L-Arginine and L-Citrulline interventions for hypertension - published in the journal Pharmaceuticals - found significant heterogeneity in the existing evidence, noting that inconsistencies in study design make it difficult to precisely quantify effect size, and that not all translational studies may have influenced vascular reactivity in the same way

mansoni Trx1 [18], DTNB, H 2 O 2 , t-butyl hydroperoxide, L-cysteine, sodium selenite, lipoic acid, lipoamide, alloxan, dehydroascorbic acid, and ubiquinone by monitoring the oxidation of NADPH