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Versus other triple/multi-agonists in development : survodutide (GLP-1/GCGR Boehringer Ingelheim), mazdutide (GLP-1/GCGR Eli Lilly), orforglipron (oral non-peptide GLP-1 Eli Lilly), HRS9531 (GLP-1/GIP Hengrui): each represents a distinct signaling architecture