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6 In the U.S., GLP-1 RA prescriptions for adults with overweight or obesity increased 586.7% from 2019 to 2024 (Fair Health, 2025), the report authors wrote

Users who push through the initial discomfort typically report minimal ongoing issues once stabilized at their maintenance dose

I would also be concerned with people who already experience constipation or slow transit time, as it can further reduce it

Attempting to disassemble a pen to access the medication inside voids sterility, risks contamination, and damages the peptide through exposure to air and temperature fluctuation