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A missense variant in the GIPR, E354Qwhereby a glutamine (Q) at amino acid position 354 replaces a glutamic acid (E), identified in a genome-wide association study (GWAS), is linked with increased risk of T2D and higher BMI (Speliotes et al., 2010)

The dual GIP/GLP-1 mechanism of tirzepatide versus semaglutide does not guarantee worse digestive effects for every individual, even though the population-level data suggests slightly higher incidence

The hazard ratio and 95% confidence interval did not reveal a significant difference between tirzepatide or insulin glargine treatment (HR, 0.74

You will need to show up for clinic visits regularly, sometimes for over a year