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These receptors play essential roles in neuroendocrine regulation, melanocortin pathway mapping, immunomodulatory activity, and behavioral response modulation within controlled studies

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Nevertheless, the data presented here overall extend the importance of HPX and heme clearance from biological fluids, including plasma, and implicate a previously unanticipated and potentially key role for the HPX system in the regulation of many aspects of heme-linked iron homeostasis in health and disease

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