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Wang L, Wang Y, Chen Y, Liu B, Chou D, Bian X, Li R, Wang M, Zheng C (2023) Rhynchophylline ameliorates cerebral ischemia by improving the synaptic plasticity in a middle cerebral artery occlusion induced stroke model

Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low

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showed the impact of gut microbiota on the fate of CD8 + T-cells through the production of SCFAs in mice consuming a high-fiber diet (Figure 1) (171)