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Use of the pharmacological inducer of ferroptosis, RSL3, elicited a similar level of lipid peroxidation in macrophages compared to H 2 O 2 , while the ferroptosis inhibitor, liproxstatin-1, significantly reduced the H 2 O 2 -induced cytotoxicity in macrophages

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[121] demonstrated in a rat model that chronic administration of LC reduces blood pressure and attenuates the inflammatory process associated with arterial hypertension

This high-throughput platform offers robust cross-species selectivity profiling of compounds, thereby providing critical support for preclinical in vivo studies and high-throughput screening campaigns