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Stress, environmental pollution, diseases, inflammations or an unbalanced diet can also lead to an increased glutathione consumption in the cells

FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis

These observations were consistent regardless of age, sex, or race of the participants

Korsten M, Matsuzaki S, Feinman L, Lieber C