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In this regard, the amylin analogue pramlintide has been demonstrated to reduce the bone resorption biomarker C-terminal telopeptide of type I collagen (CTX-1) during weight loss [10]

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Jakob Langer and Hiroshi Horio are employees of Novo Nordisk Pharma Ltd., Japan

In 1967, Perley and Kipnis conducted a further study in which they showed that the insulin produced during the incretin effect in humans accounted for more than half of the total insulin secreted by oral glucose ingestion (Perley and Kipnis, 1967)