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More colon motility (the need to go to the bathroom) and better microbiota balance may help lower inflammation in the colon and speed up the removal of carcinogens (Vitaglione, 2012

The FDA has issued warnings about thyroid cancer risk based on animal studies that connected these drugs to medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

Excess water can dilute the serum, reducing its effectiveness

Most patients lose 25 pounds in the first four weeks while on the starting dose of 0.25 mg, though some experience minimal change initially