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The best way to keep water in the skin is to increase your intake of healthy fats to strengthen your skin barrier

9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemms canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow

Studies show that, at the right dosage, oral semaglutide agonists are as effective as injectables

Here's how retatrutide compares: Why the Difference Matters A 2-3% difference sounds small on paper, but in practice it adds up: Example: 240-pound individual Semaglutide (15%): 36 pounds lost Tirzepatide (22%): 53 pounds lost Retatrutide (24%): 58 pounds lost That extra 5 pounds from retatrutide vs tirzepatide might be the difference between reaching a goal weight or falling just short