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The reactive thiol (SH) group on its cysteine residue carries its antioxidant activity

To extend these findings in vivo, we analyzed liver tissues from high-fat diet (HFD) mice treated with metformin, a pharmacological agent that lowers systemic glucose by suppressing hepatic gluconeogenesis [17]

10.1016/j.celrep.2014.04.037 143 NabeS.YamadaT.SuzukiJ.ToriyamaK.YasuokaT.KuwaharaM.et al (2018)

In a retrospective cohort study, supplemented with a nested case-control study, using two US administrative databases, Liang et al (2019) found a non-significant trend toward increased risk of thyroid cancer with exenatide (OR 1.46, 95% CI 0.982.19) (9)