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At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

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[1] The authors framed the observed metabolic shifts as a direct effect on lipid handling in the model rather than appetite suppression